ASSOCIATION BETWEEN SLEEP DISORDERED BREATHING AND GLUCOSE METABOLISM IN EARLY PREGNANCY

TOPIC: Sleep Disorders TYPE: Original Investigations PURPOSE: disordered breathing (SDB) is common in pregnancy. A relationship has been described late pregnancy between SDB and abnormal glucose metabolism, gestational diabetes mellitus (GDM). However, it remains unclear whether this starts early or develops following exposure to pregnancy.The goal of the current study examine association its severity with metabolism METHODS: Eligible participants were women singleton pregnancies who had risk factors for obstructive sleep apnea such as body mass index (BMI) ≥ 27 kg/m2 habitual snoring. Exclusion criteria included chronic steroid therapy, history pregestational diabetes, use continuous positive airway pressure.Participants underwent in-home level III testing (HSAT) homeostatic model assessment (HOMA) based on fasting C-peptide levels We derived measures (respiratory-event (REI) oxygen saturation (ODI)) parameters (insulin resistance (HOMA-IR) ꞵ-cell function (HOMA-%B)). performed linear regression analysis variance parameters. Models adjusted age at testing, maternal age, BMI, ethnicity, race. RESULTS: 61 192 (32%) diagnosed OSA REI values 5 events/hour. HSAT HOMA a median (interquartile range) 11 (3) 15 (4) weeks, respectively. Women higher insulin compared those without. REI, value, was significantly associated HOMA-IR (B=0.18, p=0.041) after adjustment covariates, while diagnosis (REI events/hour) not adjusting BMI (p>0.05).ODI prior covariates (B=0.22, p=0.002) but dropped below significance (p=0.24). There no significant associations ODI HOMA-%B (p>0.34). CONCLUSIONS: Our results support that increasing severity, measured by increased values, This because relationships are largely unstudied. CLINICAL IMPLICATIONS: data suggest may enter GDM, instead developing over course could imply screening treatment should occur earlier Further studies needed investigate if improve metabolism. DISCLOSURES: No relevant Alice Bai, source=Web Response Ghada Bourjeily, Margaret Bublitz, patrick catalano, Niharika Mehta, Geralyn Messerlian, Laura Sanapo,